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A Leper contracting a disease.

Diseases The symbol for Diseases are negative conditions functionally similar to Quirks, that are sometimes contracted by heroes from enemy attacks, curios, traps, and occasionally at the end of a dungeon.

Most diseases are only harmful, giving significant penalties to any of a hero's stats, particularly Resists, MAX HP, and ACC. However some diseases also carry a positive buff, namely Rabies, which grants +15% DMG but -10 ACC and The Fits which grants +3 SPD but -5 ACC and -5% CRIT.

Diseases last until removed. They can be cured in the Sanitarium for some gold (where there is a chance of multiple diseases being cured at once depending on upgrade level) or by using the camping skills from the Grave Robber or the Plague Doctor (which will cure all the diseases on the targeted hero). Additionally, the FlagellantThe Crimson Court DLC can cure one of his own diseases with one of his camping skills.

The chance of contracting a disease at the end of a dungeon is 32% - (33% * Disease Resist), with a minimum of at least 5%. You can only get diseases at the end of a dungeon if the hero's Resolve Level is at least 2. A hero can have at most 3 diseases at once; if they acquire a new one, it will replace an old disease picked at random.

List of Diseases[]

Disease Effect
Bad Humors -20% MAX HP
Black Plague -75% Blight Resist
-75% Disease Resist
-10% MAX HP
-5 SPD
Bulimic -20% Healing Skills while Camping
Creeping Cough -20% DMG
Ennui -25% Virtue Chance
Grey RotExclusive to The Color of Madness DLC +20% MAX HP
-10 ACC
-10% DMG
Hemophilia -50% Bleed Resist
Hysterical Blindness -20 ACC if Stress above 70
Lethargy -4 SPD
Rabies +15% DMG
-10 ACC
Scurvy -40% Bleed Resist
-40% Move Resist
Sky TaintExclusive to The Color of Madness DLC +20% Stress
-20% Bleed Resist
-20% Blight Resist
Spasm of the Entrails -20% Healing Skills while Camping
Spotted Fever -50% Blight Resist
Syphilis -5 ACC
-10% DMG
-10% MAX HP
Tapeworm +100% Food Consumed
60% chance to interact with "Food" curios (steals loot)
Tetanus -5 ACC
-5% CRIT
The Ague -10% DMG
-3 SPD
-10% MAX HP
The Fits +3 SPD
-5 ACC
-5% CRIT
The Red Plague -75% Bleed Resist
-10% MAX HP
-5% CRIT
The Runs -20 DODGE
-10% MAX HP
The Worries +30% Stress
Vertigo -50% Move Resist
Vampiric Spirits -50% Debuff Resist
Wasting Sickness -50% Disease Resist

The Crimson CurseThe Crimson Court DLC[]

The Crimson Court DLC adds a new unique disease known as the Crimson Curse. Usually it can only be contracted by fighting Bloodsucker enemies, and it has several unique properties, such as conferring particular buffs and debuffs that change over time. Any character with the Curse cannot have any other diseases, and any disease they had will be removed upon acquiring the Curse.

Disease Resist[]

Heroes' resistance to diseases is one of two resistances that isn't increased by Resolve Level, the other being Death Blow resistance.

The list of heroes by their disease resistance, from highest to lowest:

Disease Resist
Plague Doctor Occultist Flagellant Arbalest Musketeer Crusader
Plague Doctor Occultist FlagellantThe Crimson Court DLC Arbalest Musketeer Crusader
50% 40% 40% 30% 30% 30%
Grave Robber Hellion Highwayman Houndmaster Man-at-Arms Vestal
Grave Robber Hellion Highwayman Houndmaster Man-at-Arms Vestal
30% 30% 30% 30% 30% 30%
Shieldbreaker Abomination Antiquarian Bounty Hunter Jester Leper
ShieldbreakerExclusive to The Shieldbreaker DLC Abomination Antiquarian Bounty Hunter Jester Leper
30% 20% 20% 20% 20% 20%

Attacks that can cause Diseases[]

Monster Attack(s) Disease Chance
Ghoul Ghoul.png Howl The Worries 5%
Maggot Maggot.png Grave Nibble Any 15%
Swine Wretch Swine Wretch.png Vomit Any 33%
Carrion Eater Carrion Eater.png Munch Any 7% (Veteran)
9% (Champion)
Fungal Artillery Fungal Artillery.png Rain of Blight Any 15%
Rabid Gnasher Rabid Gnasher.png Rabid Rush Rabies 10%
Crone Crone.png Fetid Censer Any 7% (Veteran)
9% (Champion)
Sea Maggot Sea Maggot.png Brine Any 8%
Deep Stinger Deep Stinger.png Salty Gouge



The Shrieker Shrieker.png Regurgitate Any 15%
Thing from
the Stars

Exclusive to The Color of Madness DLC
The Thing.png Phase Gnaw Sky Taint 20% (Apprentice)
22% (Veteran)
25% (Champion)

Curios that can cause Diseases[]

Name Curio Disease Chance
Decorative Urn Decorative Urn.png Creeping Cough


Iron Maiden Iron Maiden.png Tetanus


Dinner Cart Dinner Cart.png Any 25%
Makeshift Dining


Makeshift Dining Table.png Any 25%
Pile of Bones Pile of Bones.png Any 25%
Beast Carcass Beast Carcass.png Rabies 28.6%
Shallow Grave Shallow Grave.png Any 50%
Bas-Relief Bas-Relief.png Any 8.3%
Brackish Tide Pool Brackish Tide Pool.png Any 25%
Fish Carcass Fish Carcass.png The Red Plague 16.7%




Damned Fountain Damned Fountain.png Crimson Curse 20%
Forgotten Delicacies Forgotten Delicacies.png Crimson Curse


Hooded Shrew Hooded Shrew.png Any 7.6%
Wizened Shrew Wizened Shrew.png Any 7.6%
Pile of Strange Bones Pile of Strange Bones.png Crimson Curse 10%
Wine Crate Wine Crate.png Crimson Curse 16.7%


The Carrion Eater, Thing From The Stars, and Crone have the only effects that increase Disease chance at higher levels.